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Alfred Singer, M.D.

Portait Photo of Alfred Singer
Experimental Immunology Branch
Head, Lymphocyte Development Section
Branch Chief
Center for Cancer Research
National Cancer Institute
Building 10, Room 4B36
Bethesda, MD 20892


Dr. Singer received his M.D. from Columbia University and his clinical training at the Columbia-Presbyterian Medical Center. He was a fellow in immunology at the Rockefeller University before coming to the NCI. He is chief of the Experimental Immunology Branch and his research interests are in lymphocyte recognition and development, especially the molecular and cellular recognition signals that result in self/nonself discrimination during early development.


Lymphocyte Development The differentiation of immature CD4+8+ (double positive, DP) thymocytes into mature T cells is the key event in T cell development as it gives rise to functional T cells and determines the mature T cell repertoire. Our research seeks to elucidate the molecular mechanism by which thymic selection generates an MHC-restricted T cell receptor repertoire that is coordinated with CD4 and CD8 coreceptor expression and appropriate T cell function.

This page was last updated on 4/10/2014.